추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
S24-18, monoclonal
양식
buffered aqueous glycerol solution
분자량
antigen predicted mol wt 300 kDa
종 반응성
human, mouse, rat
농도
1 mg/mL
기술
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
rat ... Itpr1(25262)
일반 설명
Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) is highly expressed in the rat brain and is also seen in the heart. It possesses an inositol-triphosphate binding domain, a channel-forming region and a regulatory region. ITPR1 is composed of 2749 amino acids. The gene ID for the protein is 25262.
특이성
Detects ~300 kDa. Does not recognize type 2 or type 3 IP3R′s.
면역원
Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1
애플리케이션
Monoclonal Anti-ITPR1 antibody produced in mouse has been used for Western blotting.
생화학적/생리학적 작용
Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) takes part in Ca2+ signaling on binding to its ligand, inositol 1,4,5-trisphosphate.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration.
Oliveira AG
Liver International : Official Journal of the International Association For the Study of the Liver, 35(4), 1162-1171 (2015)
Yi Sun et al.
The Biochemical journal, 449(1), 39-49 (2012-09-27)
Binding of IP3 (inositol 1,4,5-trisphosphate) to the IP3-binding core (residues 224-604) of IP3Rs (IP3 receptors) initiates opening of these ubiquitous intracellular Ca2+ channels. The mechanisms are unresolved, but require conformational changes to pass through the suppressor domain (residues 1-223). A
Krishna P Subedi et al.
Cellular & molecular biology letters, 17(1), 124-135 (2011-12-31)
Inositol 1,4,5-trisphosphate receptor type 1 (IP(3)R1) is already known to be highly expressed in the brain, and is found in many other tissues, including the atrium of the heart. Although the complete primary structure of IP(3)R1 in the rat brain
Barbora Chovancova et al.
Biochemical pharmacology, 171, 113695-113695 (2019-11-11)
Several papers have reported that calcium channel blocking drugs were associated with increased breast cancer risk and worsened prognosis. One of the most common signs of breast tumors is the presence of small deposits of calcium, known as microcalcifications. Therefore
William E Greineisen et al.
Cell calcium, 56(3), 169-180 (2014-07-14)
There is well-established variability in the numbers of lipid bodies (LB) in macrophages, eosinophils, and neutrophils. Similarly to the steatosis observed in adipocytes and hepatocytes during hyperinsulinemia and nutrient overload, immune cell LB hyper-accumulate in response to bacterial and parasitic
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