추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 160 kDa
종 반응성
human, mouse, rat
농도
~1 mg/mL
기술
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... NOS1(4842)
일반 설명
Anti-NNOS antibody detects endogenous levels of total NNOS protein.
The NNOS (nitric oxide synthase 1) gene is mapped to human chromosome 12q24.22. Neuronal nitric oxide synthase is known to be expressed in skeletal muscles, the heart and the brain.
면역원
The antiserum was produced against synthesized peptide derived from human nNOS.
Immunogen Range: 818-867
Immunogen Range: 818-867
애플리케이션
Anti-NNOS antibody produced in rabbit has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
생화학적/생리학적 작용
NNOS (nitric oxide synthase 1) is responsible for the synthesis of NO (nitric oxide) as well as superoxide. Stress induces the activity of NNOS and generation of NO and results in the formation of nitrogen radicals. Elevation of nitrogen radical leads to intracellular protein damage and also induces impairment to mitochondrial transport chain components. This generally results in cellular energy deficiency. NNOS is known to regulate vasodilation in the forearm, in response to stress. Neuronal nitric oxide synthase normally functions to control the basal coronary blood flow.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Anna Svenningsson et al.
Journal of human genetics, 57(2), 115-121 (2011-12-14)
Infantile hypertrophic pyloric stenosis (IHPS) is a common cause of upper gastrointestinal obstruction during infancy. A multifactorial background of the disease is well established. Multiple susceptibility loci including the neuronal nitric oxide synthase (NOS1) gene have previously been linked to
G Catanzaro et al.
Journal of neuroimmunology, 294, 32-40 (2016-05-04)
The development of multiple sclerosis, a major neurodegenerative disease, is due to both genetic and environmental factors that might trigger aberrant epigenetic changes of the genome. In this study, we analysed global DNA methylation in the brain of mice upon
A Kumar et al.
Vitamins and hormones, 103, 147-167 (2017-01-08)
Stress is often marked by a state of hyperarousal to aid the initiation of necessary stress response for the successful management of stressful stimuli. It can be manifested as a challenge (stimulus) that requires behavioral, psychological, and physiological adaptations for
Hideshi Ihara et al.
The Biochemical journal, 474(7), 1149-1162 (2017-01-28)
We previously demonstrated different spacial expression profiles of the neuronal nitric oxide (NO) synthase (nNOS) splice variants nNOS-µ and nNOS-α in the brain; however, their exact functions are not fully understood. Here, we used electron paramagnetic resonance to compare the
Yan Yang et al.
Molecular medicine reports, 13(2), 1220-1226 (2015-12-10)
Spinal nitric oxide is involved in the mechanisms of pain generation and transmission during inflammatory and neuropathic pain. The aim of the present study was to explore the role of spinal nitric oxide in the development of bone cancer pain.
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