추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 21 kDa
종 반응성
mouse, rat, human
농도
~1 mg/mL
기술
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pSer184)
유전자 정보
human ... BAX(581)
일반 설명
Bif-1 (BAX-interacting factor 1), a membrane-curvature inducing protein is located on human chromosome 19q13. Bif-1 is also known as SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)/ Endophilin B1. It belongs to the membrane curvature-driving endophilin protein family.
면역원
The antiserum was produced against synthesized peptide derived from human Bax around the phosphorylation site of Ser184.
Immunogen Range: 143-192
Immunogen Range: 143-192
생화학적/생리학적 작용
Bif-1 (BAX-interacting factor 1) plays a vital role in apoptosis. BAX gene may act as a negative regulator of autophagy in CRC (Colorectal cancer) development. Lack of Bif-1 affects lipid homeostasis and results in obesity followed by insulin resistance.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer.
Gil J, et al.
Medical Oncology (Northwood, London, England), 34(2), 16-16 (2017)
The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria.
Simonyan L, et al.
Biochimica et Biophysica Acta - Biomembranes, 1859(6), 1144-1155 (2017)
Wnt signal transduction pathway and apoptosis: a review.
Pecina-Slaus N
Cancer Cell International, 10(1), 22-22 (2010)
Won-Kyu Ju et al.
Oxidative medicine and cellular longevity, 2020, 9410289-9410289 (2020-10-22)
[This corrects the article DOI: 10.1155/2019/8060962.].
Ying Liu et al.
Scientific reports, 6, 20453-20453 (2016-02-10)
Bif-1 is a membrane-curvature inducing protein that is implicated in the regulation of autophagy and tumorigenesis. Here, we report that Bif-1 plays a critical role in regulating lipid catabolism to control the size of lipid droplets and prevent the development
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