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Merck
모든 사진(4)

Key Documents

SAB4504108

Sigma-Aldrich

Anti-phospho-TIP60 (pSer86) antibody produced in rabbit

affinity isolated antibody

동의어(들):

KAT5, Lysine acetyltransferase 5

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.43

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 58 kDa

종 반응성

rat, mouse, human

농도

~1 mg/mL

기술

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

phosphorylation (pSer86)

유전자 정보

human ... KAT5(10524)

일반 설명

The TIP60 (HIV1 (human immunodeficiency virus 1)-TAT interactive protein) gene is mapped to human chromosome 11q13.1. It is ubiquitously expressed and evolutionarily conserved. The encoded protein, Tip60 belongs to the MYST (Moz, Ybf2/Sas3, Sas2 and TIP60) family.

면역원

The antiserum was produced against synthesized peptide derived from human TIP60 around the phosphorylation site of Ser86.

Immunogen Range: 52-101

애플리케이션

TIP60 (HIV1-TATinteractive protein) possess acetyltransferase activity and participates in chromatin remodeling and DNA damage repair. TIP60 is involved in protein stabilization and protein function modulation. The presence of chromodomain and MYST domain in its structure enables acetylation of both histone and non-histone proteins. TIP60 in association with androgenic receptors and transcription factors can control gene transcription and cell cycle process. TIP60 mediates p53 action to induce apoptosis. TIP60 inhibits Hepatitis B virus infection. TIP60 acts as a haploinsufficient tumor suppressor.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Cellular functions of TIP60
Sapountzi V, et al.
The International Journal of Biochemistry & Cell Biology, 38(9), 1496-1509 (2006)
TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
Rajagopalan D, et al.
PLoS Pathogens, 13(10), e1006681-e1006681 (2017)
TIP60 complex inhibits HBV transcription
Nishitsuji H, et al.
Journal of Virology, JVI-01788 (2018)
Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell
Ashraf W, et al.
Journal of Experimental & Clinical Cancer Research, 36(1), 188-188 (2017)
Marcella M Authiat et al.
Neural plasticity, 2022, 3172861-3172861 (2022-03-04)
Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ 42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine

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