SAB4504020

Anti-phospho-ATP-Citrate Lyase (pSer⁴⁵⁴) antibody produced in rabbit

affinity isolated antibody

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 120 kDa
• 종 반응성: mouse, rat, human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:1000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: P53396
• UniProt 수납 번호: P53396
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer454)
• 유전자 정보: human ... ACLY(47)

설명

일반 설명

ATP citrate lyase (ACLY) is encoded by the gene mapped to human chromosome 17q21.2. It is localized in the cytoplasm and is widely expressed in mammalian tissues.. ACLY is a 440 KDa tetrameric protein containing four apparently identical subunits.

면역원

The antiserum was produced against synthesized peptide derived from human ATP-Citrate Lyase around the phosphorylation site of Ser454.

Immunogen Range: 420-469

애플리케이션

Anti-phospho-ATP-Citrate Lyase (pSer454) antibody produced in rabbit has been used in immunohistochemistry.

생화학적/생리학적 작용

ACLY (ATP citrate lyase) is responsible for cleavage of mitochondria-derived citrate to generate oxaloacetic acid (OAA) and acetyl-CoA, which is required for lipid biogenesis. This enzyme couples energy metabolism with fatty acids and facilitates cell growth. In addition, ACLY is also essential for DNA-damage-induced histone acetylation. ACLY is upregulated in several types of cancers and is associated with cancer cell proliferation. Elevated expression of the gene leads to the development of breast cancer. Thus, ACLY -related inhibitors can be considered as a potential strategy for treating breast cancer.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable