추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 59 kDa
종 반응성
rat, human, mouse
농도
~1 mg/mL
기술
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... RPS6KB1(6198)
일반 설명
Ribosomal protein S6 kinase B1 (RPS6KB1) also known as S6Ka or S6K1 is an isoform of S6 kinases, which belong to AGC serine/threonine kinases of the ribosomal S6 kinase (RSK) family. S6K1 is encoded by the gene mapped to human chromosome 17q23. S6K1 is activated on phosphorylation of its domains, which include T-loop and hydrophobic motif and Ser-Pro/Thr-Pro residues at C- terminal.
면역원
The antiserum was produced against synthesized peptide derived from human S6K.
Immunogen Range: 261-310
Immunogen Range: 261-310
생화학적/생리학적 작용
Ribosomal protein S6 kinase B1 (RPS6KB1), or S6K1, regulates cell size and progression through cell cycle. It also inhibits pro-apoptotic protein bcl-2-associated death promoter (BAD) and promotes cell survival. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1, mTORC1-S6K1 complex regulates various cellular processes, such as transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. Overexpression of S6 kinase 1 (S6K1) leads to many disorders , including diabetes, aging, and cancer. Development of organometallic S6K1 inhibitors such as EM5 and FL772, might be a potential method for the treatment of diseases caused by aberrant activity of S6K1. The increased expression of S6K1 in obesity results in adipose tissue dysfunction via a close association with insulin resistance and inflammation development. Elevated expression of S6K1 is observed in breast cancer patients.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
R M Biondi et al.
The EMBO journal, 20(16), 4380-4390 (2001-08-14)
PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3-kinase-dependent manner in response to insulin/growth factors signalling. Activation entails phosphorylation of these kinases at two residues, the T-loop and the hydrophobic motif. PDK1 activates S6K, SGK and
Brian Magnuson et al.
The Biochemical journal, 441(1), 1-21 (2011-12-16)
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. TORC1 functions as an environmental sensor by integrating
F J Couch et al.
Cancer research, 59(7), 1408-1411 (1999-04-10)
The application of comparative genomic hybridization to the analysis of genetic abnormalities in breast carcinoma has consistently revealed that chromosome region 17q22-24 is a frequent site of gene amplification in this type of cancer. As part of an examination of
Andrea R Marti et al.
Frontiers in neural circuits, 11, 70-70 (2017-11-01)
Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits in cognitive functions, impaired alertness and increased risk of errors and accidents. Disturbed circadian rhythmicity resulting from night shift work
Jie Qin et al.
Journal of medicinal chemistry, 58(1), 305-314 (2014-10-31)
Aberrant activation of S6 kinase 1 (S6K1) is found in many diseases, including diabetes, aging, and cancer. We developed ATP competitive organometallic kinase inhibitors, EM5 and FL772, which are inspired by the structure of the pan-kinase inhibitor staurosporine, to specifically
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