추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 15 kDa
종 반응성
human
농도
~1 mg/mL
기술
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CYTL1(54360)
일반 설명
Anti-CYTL1 antibody detects endogenous levels of total CYTL1 protein.
The CYTL1 (cytokine like 1) gene is mapped to human chromosome 4p16.2. The gene was first discovered in CD34(+) cells of the bone marrow and cord blood. The encoded protein is predominantly expressed in chondrocytes.
면역원
The antiserum was produced against synthesized peptide derived from human CYTL1.
Immunogen Range: 61-110
Immunogen Range: 61-110
생화학적/생리학적 작용
In vitro studies reveal that Cytl1 (cytokine like 1) acts as an autocrine or paracrine regulatory factor in the process of cartilage formation. CYTL1, being homologous with IL-2 (interleukin-2), is considered as a potential cytokine that is involved in regulating immune responses. CYTL1 is known to be associated with the pathogenesis of rheumatoid arthritis and osteoarthritis.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Tanja Vukićević et al.
Journal of the American Society of Nephrology : JASN, 30(5), 795-810 (2019-04-17)
Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. This pathway fine-tunes renal water reabsorption and urinary concentration, and its perturbation
Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model.
Tomczak A
Proteins: Structure, Function, and Genetics, 79(4), 1277-1292 (2011)
Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.
Wang X
Journal of Immunology, 196(10), 4090-4099 (2016)
Yue Tan et al.
Frontiers in immunology, 8, 478-478 (2017-05-10)
The initial infection and transmission of HIV-1 requires C-C chemokine receptor type 5 (CCR5). Here, we report that the membrane-proximal region (MPR, aa 22-38) of CCR5 participates in the infection of HIV-1. First, MPR-specific antibodies elicited in mice dose-dependently inhibited
Xiaolin Wang et al.
Oncoimmunology, 8(5), e1577126-e1577126 (2019-05-10)
CYTL1 is a novel cytokine that was first identified in CD34+ hematopoietic cells. We previously prepared recombinant CYTL1 and verified that it chemoattracted human monocytes via the CCR2/ERK pathway. It has been reported that CYTL1 plays contradictory roles in neuroblastoma
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