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Merck
모든 사진(3)

Key Documents

SAB4502195

Sigma-Aldrich

Anti-PI3-kinase p85-α antibody produced in rabbit

affinity isolated antibody

동의어(들):

GRB1, P85A, PI3-kinase p85-α subunit, PI3K, PI3K p85-α

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 83 kDa

종 반응성

mouse, rat, human

농도

~1 mg/mL

기술

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... PIK3R1(5295)

일반 설명

Anti-PI3-kinase p85-α antibody detects endogenous levels of total PI3-kinase p85-α protein.
The PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) gene is mapped to human chromosome 5q13.1. It encodes for p85α regulatory subunit.

면역원

The antiserum was produced against synthesized peptide derived from human PI3-kinase p85-alpha/gamma.

Immunogen Range: 436-485

애플리케이션

Anti-PI3-kinase p85-α antibody produced in rabbit has been used in western blotting.

생화학적/생리학적 작용

PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) is known to mediate immune cell differentiation, development and function. Dominant mutations of PIK3R1 causes hyperactivation of the PI3K signaling pathway, leading to immunodeficiency and also SHORT syndrome (short stature, hyperextensibility, hernia, ocular depression, Rieger anomaly, and teething delay). PI3K is an important part of insulin and growth factor signaling. PIK3R1 gene is considered to be intolerant to functional variation among the human population. In human, downregulation of PIK3R1 is observed in many types of cancer. PIK3R1 is regarded as a tumor suppressor gene. PIK3R1 mediates tumorigenesis and malignant progression. The gene harbors receptor tyrosine kinases activity and participates in the activation of class IA PI3Ks.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Qiong Wu et al.
Cell death & disease, 9(2), 232-232 (2018-02-16)
G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in
?-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Yang Y
Nature Communications, 6:7369 (2015)
Aberrant low expression of p85? in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b.
Chen Y
Oncogene, 36(33), 4692-4705 (2017)
Oncogenic mutations in GNAQ occur early in uveal melanoma.
Onken MD
Investigative Ophthalmology & Visual Science, 49(12), 5230-5234 (2008)
Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature.
Petrovski S
Journal of clinical immunology, 36(5), 462-471 (2016)

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