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Merck
모든 사진(1)

주요 문서

SAB4300676

Sigma-Aldrich

Anti-Vimentin Antibody

rabbit polyclonal

동의어(들):

Anti-FLJ36605, Anti-VIM

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

제품명

Anti-Vimentin antibody produced in rabbit, affinity isolated antibody

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

~57 kDa

종 반응성

monkey, mouse, human, rat

농도

1 mg/mL

기술

western blot: 1:500-1:1000

동형

IgG

면역원 서열

(G-Q-V-I-N)

NCBI 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... Vimentin(7431)

일반 설명

Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. It is located on human chromosome 10p13.

The antibody detects endogenous level of total Vimentin protein.

면역원

Peptide sequence around aa. 452-456 (G-Q-V-I-N), according to the protein NP_003371.2

생화학적/생리학적 작용

Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

표적 설명

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

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문서 라이브러리 방문

The gene encoding human vimentin is located on the short arm of chromosome 10
Ferrari S, et al.
American Journal of Human Genetics (1987)
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks
Janmey PA, et al.
The Journal of Cell Biology (1991)
Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions
Schafer G, et al.
Journal of Virology (2017)
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins
Liu PF, et al.
PLoS ONE (2017)
Toshifumi Murai et al.
Journal of surgical oncology, 109(7), 684-689 (2014-01-24)
Epithelial-to-mesenchymal transition (EMT) is considered to play an important role in cancer invasion and metastasis. The mRNA levels of an epithelial marker (E-cadherin), mesenchymal marker (vimentin), and Zeb-1 were measured in 11 gastric cancer cell lines. Functional analysis was performed

Global Trade Item Number

SKUGTIN
SAB4300676-100UG4061833236352

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