SAB4300470

Anti-CTNNB1 (Ab-33) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-CTNNB antibody produced in rabbit, Anti-DKFZp686D02253 antibody produced in rabbit, Anti-FLJ25606 antibody produced in rabbit, Anti-FLJ37923 antibody produced in rabbit, Anti-catenin (cadherin-associated protein), beta 1, 88kDa antibody produced in rabbit
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: ~92 kDa
• 종 반응성: human, rat, mouse
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (L-D-S-G-I)
• NCBI 수납 번호: NP_001091679.1
• UniProt 수납 번호: P35222
• 응용 분야: research pathology
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CTNNB1(1499)

설명

일반 설명

Catenin beta-1 (CTNNB1) encoding β-catenin, belongs to armadillo-repeat family. In human chromosome, the gene CTNNB1 is localized on 3p22.1.

면역원

Peptide sequence around aa. 31-35 (L-D-S-G-I), according to the protein CTNNB1.

생화학적/생리학적 작용

Catenin beta-1 (CTNNB1) is a signalling molecule in the nucleus and anchors actin cytoskeleton to cadherin-based adherens junctions. Phosphorylation causes dissociation of β-catenin from E-cadherin and degradation by proteasome pathway. β-catenin is a key molecule in wingless/integrated (wnt) signalling. β-catenin forms a complex with kindlin 2 and T-cell factor 4 (TCF4) to regulate wnt target gene expression. Mutations in adenomatous polyposis coli (APC) and CTNNB1 gene affects β-catenin intracellular localization and stability, contributing to aberrant expression of wnt/β-catenin in malignant melanoma. β-catenin is a major oncoprotein, which downregulates death associated protein kinase 2 (Dapk2) and inhibits anoikis of cancer cells. β-catenin expression is suppressed and its downstream gene transcription function is regulated by a tumor suppressor protein fragile histidine triad (Fhit). High expression of mucin 1 (MUC1), translocates β-catenin out of the nucleus and inhibits β-catenin regulated cell proliferation. Somatic mutations of CTNNB1 in glycogen synthase kinase 3β−casein kinase 1 (GSK-3β−CK1) phosphorylation site results in loss of phosphorylation of β-catenin. This causes aberrant wnt-signalling and leads to adrenocortical adenomas and adrenocortical carcinoma.

특징 및 장점

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표적 설명

Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable