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Merck
모든 사진(2)

Key Documents

SAB4300464

Sigma-Aldrich

Anti-APP (Ab-668) antibody produced in rabbit

affinity isolated antibody

동의어(들):

Anti-AAA antibody produced in rabbit, Anti-ABETA antibody produced in rabbit, Anti-ABPP antibody produced in rabbit, Anti-AD1 antibody produced in rabbit, Anti-amyloid beta (A4) precursor protein antibody produced in rabbit

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

100-140 kDa

종 반응성

human, mouse, rat

농도

1 mg/mL

기술

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

동형

IgG

면역원 서열

( A-V-T-P-E)

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... APP(351)

일반 설명

Amyloid β precursor protein (APP) is a type I transmembrane glycoprotein. The APP gene is mapped to human chromosome 21q21.3 and encodes various isoforms due to alternative splicing events. APP displays the ubiquitous expression, although, high levels are observed in the brain. It comprises a large ectodomain, short cytoplasmic tail, E1, and E2 domains. The E1 domain harbors a growth factor-like domain (GFLD) and a copper-binding domain (CuBD).

면역원

Peptide sequence around aa. 666-670 ( A-V-T-P-E ), according to the protein APP.

애플리케이션

Anti-APP (Ab-668) antibody produced in rabbit has been used in:
  • immunohistochemistry
  • immunolabeling
  • western blotting
  • immunoprecipitation

생화학적/생리학적 작용

Amyloid β precursor protein (APP) serves as a precursor of amyloid β (Aβ) peptide. It participates in synaptic function, trans-cellular synaptic adhesion, and in the anterograde transport of the virus.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

표적 설명

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Prasanna Satpute-Krishnan et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16532-16537 (2006-10-26)
Fast anterograde transport of membrane-bound organelles delivers molecules synthesized in the neuronal cell body outward to distant synapses. Identification of the molecular "zipcodes" on organelles that mediate attachment and activation of microtubule-based motors for this directed transport is a major
Eglė Jakubauskienė et al.
Gene, 766, 145146-145146 (2020-09-18)
The removal of introns from mRNA precursors (pre-mRNAs) is an essential step in eukaryotic gene expression. The splicing machinery heavily contributes to biological complexity and especially to the ability of cells to adapt to altered cellular conditions. Hypoxia also plays
Rui Zhang et al.
CNS neuroscience & therapeutics, 26(2), 228-239 (2019-08-01)
As a normal physiological process, sleep has recently been shown to facilitate clearance of macromolecular metabolic wastes from the brain via the glymphatic system. The aim of the present study was to investigate pathophysiological roles of astroglial aquaporin 4 (AQP4)
Jenna M Ramaker et al.
Frontiers in molecular neuroscience, 9, 130-130 (2016-12-10)
Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a
Yuqian Guo et al.
Molecular medicine reports, 23(4) (2021-03-03)
Ginsenoside Rg1 (Rg1) is traditional Chinese medicine with neuroprotective activity. Previous studies have demonstrated that Rg1 improves Alzheimer's disease (AD) and alters gut microbiology, but its mechanism remains to be elucidated, and thus far, its use in the treatment of AD has not

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