SAB4300411

Anti-BRCA1 (Ab-1524) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit
• MDL number: MFCD01092286
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: ~220 kDa
• 종 반응성: human
• 농도: 1 mg/mL
• 기술: indirect immunofluorescence: 1:100-1:200
• 동형: IgG
• 면역원 서열: (Y-P-S-Q-E)
• NCBI 수납 번호: NP_009225.1
• UniProt 수납 번호: P38398
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... BRCA1(672)

설명

면역원

Peptide sequence around aa. 1522-1526 (Y-P-S-Q-E), according to the protein BRCA1.

특징 및 장점

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표적 설명

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable