SAB4300259

Anti-phospho-AKT1/AKT2/AKT3 (pTyr³¹⁵/pTyr³¹⁶/pTyr³¹²) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-AKT antibody produced in rabbit, Anti-DKFZp434N0250 antibody produced in rabbit, Anti-PKBB antibody produced in rabbit, Anti-v-akt murine thymoma viral oncogene homolog 1 / 2 / 3 (protein kinase B, gamma) antibody produced in rabbit
• MDL number: MFCD03096597
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: ~60 kDa
• 종 반응성: human, rat, mouse
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (P-E-YP-L-A)
• NCBI 수납 번호: NP_001014431.1; NP_001617.1; NP_005456.1
• UniProt 수납 번호: P31751
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr315/pTyr316/pTyr312)
• 유전자 정보: human ... AKT1(207) , AKT2(208) , AKT3(10000)

설명

면역원

Peptide sequence around phosphorylation site of tyrosine 315/316/312 (P-E-Y(p)-L-A), according to the proteins AKT1/AKT2/AKT3.

특징 및 장점

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표적 설명

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. /IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable