추천 제품
생물학적 소스
mouse
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
JLT-12, monoclonal
양식
buffered aqueous solution
분자량
antigen ~38 kDa
종 반응성
rat, human, mouse, bovine, rabbit, goat
농도
~1.0 mg/mL
기술
immunoblotting: 0.5-1 μg/mL using rat skeletal muscle extract
immunofluorescence: suitable
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human skeletal muscle sections
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TNNT1(7138)
일반 설명
Anti-Troponin T antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the JLT-12 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with purified Troponin T from rabbit skeletal muscle. Troponin T (TNNT) is the tropomyosin binding subunit of the troponin complex. Three genes have evolved to encode the cardiac (TNNT2), slow (TNNT1) and fast (TNNT3) skeletal muscle Troponin T proteins, which are specifically expressed in cardial, slow and fast skeletal muscles, respectively.
면역원
purified Troponin T from rabbit skeletal muscle
애플리케이션
- Anti-Troponin T antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
생화학적/생리학적 작용
Troponin T (TNNT) participates in calcium regulation of actin thin filament function and is required for the contraction of striated muscles. Levels of cardiac Troponin T serve as a sensitive biomarker of myocardial injury. Troponin T has also been suggested as a potential marker in diagnosis of skeletal myopathies including amyotrophic lateral sclerosis (ALS).
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Cardiac troponin T and fast skeletal muscle denervation in ageing
Xu Z, et al.
Journal of Cachexia, Sarcopenia and Muscle, 8(5), 808-808 (2017)
P A Anderson et al.
Circulation research, 65(4), 1087-1093 (1989-10-01)
Myocardium is generally thought to express no more than two isoforms of troponin T (TnT). We have recently reported that TnT purified from rabbit myocardium is resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis into five proteins (TnT1, TnT2, TnT3, TnT4
Lukas Mach et al.
Acta neurologica Belgica, 116(4), 557-564 (2016-01-24)
Limited evidence suggests that specificity of cardiac troponin T (cTnT), a highly sensitive biomarker of myocardial injury, is reduced in patients with skeletal myopathies. Whether amyotrophic lateral sclerosis (ALS)-the most common motor neuron disease-could be also associated with abnormal plasma
Bin Wei et al.
Gene, 582(1), 1-13 (2016-01-18)
Troponin T (TnT) is a central player in the calcium regulation of actin thin filament function and is essential for the contraction of striated muscles. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1
The troponin complex and regulation of muscle contraction
Farah CS, et al.
Faseb Journal, 9(9), 755-767 (1995)
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