추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
H6.10, monoclonal
형태
buffered aqueous solution
분자량
antigen ~14 kDa
종 반응성
chicken, human, monkey, hamster, canine
농도
~1 mg/mL
기술
immunoblotting: 0.25-0.5 μg/mL using using histones isolated from human HeLa cells.
immunofluorescence: 5-10 μg/mL using using HeLa cells.
동형
IgG1
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... HIST1H3A(8350)
관련 카테고리
일반 설명
Histone cluster 1 H3A (HIST1H3A) belongs to the H3 histone family. The gene encoding it is localized on human chromosome 6.
Monoclonal Anti-Histone H3 (C-terminal) (mouse IgG1 isotype) is derived from the hybridoma H6.10 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the C terminal region of human Histone H3, conjugated to KLH.
면역원
a synthetic peptide corresponding to a sequence at the C terminal region of human Histone H3.
애플리케이션
Monoclonal Anti-Histone H3 (C-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
생화학적/생리학적 작용
H3.1 (Histone 3-variant 1) is involved in gene silencing as well as gene activation. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. Mutations in histone H3 were identified in various tumors.
Histone cluster 1 H3A (HIST1H3A) has been associated with DNA replication.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Histone H3. 3 mutations: a variant path to cancer
Yuen B T K and Knoepfler P S
Cancer Cell, 24(5), 567-574 (2013)
Expression patterns and post-translational modifications associated with mammalian histone H3 variants
Hake S B, et al.
The Journal of Biological Chemistry, 281(1), 559-568 (2006)
FERONIA receptor kinase contributes to plant immunity by suppressing jasmonic acid signaling in Arabidopsis thaliana
Guo H, et al
Current Biology, 28(20), 3316-3324 (2018)
Organismal differences in post-translational modifications in histones H3 and H4
Garcia B, et al.
The Journal of Biological Chemistry, 282(10), 7641-7655 (2007)
Sean M Callahan et al.
Science advances, 9(32), eade2693-eade2693 (2023-08-11)
Histone modifications control numerous processes in eukaryotes, including inflammation. Some bacterial pathogens alter the activity or expression of host-derived factors, including sirtuins, to modify histones and induce responses that promote infection. In this study, we identified a deacetylase encoded by
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