콘텐츠로 건너뛰기
Merck
모든 사진(1)

Key Documents

SAB4200602

Sigma-Aldrich

Anti-Actin (α-Sarcomeric) antibody, Mouse monoclonal

~1.0 mg/mL, clone 5C5, purified from hybridoma cell culture

동의어(들):

Anti-AA959943, Anti-ACTA1, Anti-ALPHA SKELETAL ACTIN, Anti-ALPHA1 ACTIN, Anti-ASMA, Anti-Acta-2, Anti-Acts, Anti-Actsk-1, Anti-CFTD, Anti-CFTDM, Anti-Fetal isoform of skeletal alpha-actin, G-actin, Anti-MPFD, Anti-NEM1, Anti-RP5-1068B5.2, Anti-actin, alpha 1, skeletal muscle

로그인조직 및 계약 가격 보기


About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified from hybridoma cell culture

항체 생산 유형

primary antibodies

클론

5C5, monoclonal

형태

buffered aqueous solution

분자량

antigen ~42 kDa

종 반응성

human, carp, bovine, frog, sheep, rabbit, rat, snake, guinea pig

농도

~1.0 mg/mL

기술

immunoblotting: suitable
immunohistochemistry: 1-2 μg/mL using formalin-fixed, paraffin embedded human tongue
indirect ELISA: suitable

동형

IgM

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ACTA1(58)

일반 설명

Monoclonal Anti-Actin (α-Sarcomeric) (mouse IgM isotype) is derived from the hybridoma 5C5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified rabbit striated muscle. Actin is one of the major cytoskeletal proteins in eukaryotic cells.

면역원

purified rabbit striated muscle

애플리케이션

Monoclonal Anti-Actin (α-Sarcomeric) antibody produced in mouse has been used in:
  • western blotting
  • enzyme linked immunosorbent assay (ELISA)
  • immunohistochemistry

생화학적/생리학적 작용

Actin plays an essential role in various cellular processes including cell migration, cytokinesis, vesicle transport, and contractile force generation. Pathological conditions influenced by genetic and/or environmental factors causes variations in the sarcomeric actin filaments. These variations in the actin filaments leads to the development of congenital myopathy, a genetic muscle disorder.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

적합한 제품을 찾을 수 없으신가요?  

당사의 제품 선택기 도구.을(를) 시도해 보세요.

Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Beclin 1 knockdown retards re-endothelialization and exacerbates neointimal formation via a crosstalk between autophagy and apoptosis
Ye LX, et al.
Atherosclerosis, 237(1), 146-154 (2014)
The actin cytoskeleton and actin-based motility
Svitkina T
Cold Spring Harbor Perspectives in Biology, 10(1), a018267-a018267 (2018)
Dynamic regulation of sarcomeric actin filaments in striated muscle
Ono S
Cytoskeleton (Hoboken, N.J.), 67(11) (2010)
Actin, a central player in cell shape and movement
Pollard TD and Cooper JA
Science, 326(5957), 1208-1212 (2009)
O Skalli et al.
The American journal of pathology, 130(3), 515-531 (1988-03-01)
A series of 15 rhabdomyosarcomas was examined by light microscopy, transmission electron microscopy, two-dimensional gel electrophoresis (2D-GE) and indirect immunofluorescence, the latter using monoclonal or affinity-purified polyclonal antibodies to desmin, vimentin, alpha-smooth muscle and alpha-sarcomeric (alpha-sr) actins. By light microscopy

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.