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Merck
모든 사진(5)

주요 문서

SAB4200515

Sigma-Aldrich

Anti-Arc antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

동의어(들):

Anti-Activity-regulated cytoskeleton-associated protein, Anti-Arc3.1, Anti-Arg3.1

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41
결합:
unconjugated
application:
IHC
WB
클론:
polyclonal
종 반응성:
rat, mouse, human
citations:
4
기술:
immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat brain
western blot: 1.5-3 μg/mL using U937 cell extracts

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen ~55 kDa

종 반응성

rat, mouse, human

향상된 검증

recombinant expression
Learn more about Antibody Enhanced Validation

농도

~1.0 mg/mL

기술

immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat brain
western blot: 1.5-3 μg/mL using U937 cell extracts

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ARC(23237)
mouse ... Arc(11838)
rat ... Arc(54323)

일반 설명

Activity regulated cytoskeleton associated protein (Arc) is encoded by the gene mapped to human chromosome 8q24.3.

면역원

synthetic peptide corresponding to a sequence at the C-terminal region of human Arc, conjugated to KLH. The corresponding sequence is identical in rat and mouse Arc.

생화학적/생리학적 작용

Activity regulated cytoskeleton associated protein (Arc) plays a vital role in memory formation. It also facilitates activity-dependent plasticity of dendrites. Mutation in the gene has been associated with the development of idiopathic generalized epilepsy (IGE).

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy.
Haug K
Molecular and Cellular Probes, 14, 255-260 (2000)
Insulin-induced expression of the activity-regulated cytoskeleton-associated gene (ARC) in human neuroblastoma cells requires p21ras, mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Kremerskothen J
Neuroscience Letters, 321, 153-156 (2002)
G L Lyford et al.
Neuron, 14(2), 433-445 (1995-02-01)
Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG) cDNA that is rapidly induced in neurons by activity in models
Sarah A Stern et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(9), 2179-2190 (2014-03-20)
To treat cognitive disorders in humans, new effective therapies that can be easily delivered systemically are needed. Previous studies showed that a bilateral injection of insulin-like growth factor II (IGF-II) into the dorsal hippocampus of rats or mice enhances fear
Jayme R McReynolds et al.
Neurobiology of learning and memory, 115, 49-57 (2014-09-10)
The basolateral complex of the amygdala (BLA) plays a role in the modulation of emotional memory consolidation through its interactions with other brain regions. In rats, memory enhancing infusions of the β-adrenergic receptor agonist clenbuterol into the BLA immediately after

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