추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen ~50 kDa
종 반응성
rat, human, mouse
농도
~1.0 mg/mL
기술
immunoprecipitation (IP): 2-4 μg using lysates of human HeLa cells
western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or rat NRK cells
UniProt 수납 번호
응용 분야
research pathology
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... VPS4A(27183)
mouse ... Vps4a(116733)
rat ... Vps4a(246772)
일반 설명
Vacuolar protein sorting-associated protein 4 (Vps4) is a member of the AAA protein family (ATPases associated with diverse cellular activities). Vps4 exists as two orthologs in humans (VPS4A and VPS4B). The gene encoding Vps4A is mapped to chromosome 16q22, while the gene for Vps4B resides on chromosome 18q21-q22.
특이성
Anti-VPS4 recognizes human, mouse, and rat VPS4A and VPS4B.
애플리케이션
Anti-VPS4 antibody has been used in
- immunoprecipitation
- immunofluorescence Confocal Microscopy
- immunohistochemistry
- western blotting
생화학적/생리학적 작용
Vacuolar protein sorting-associated protein 4 (VPS4) mediates endosomal membrane protein sorting, retroviral budding and cytokinesis by recognizing membrane-associated ESCRT-III assemblies and catalyzing their disassembly.
물리적 형태
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
저장 및 안정성
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4
Thoresen SB, et al.
Nature Cell Biology, 16(6), 550-560 (2014)
The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein
Hasegawa T, et al.
PLoS ONE, 6(12), e29460-e29460 (2011)
VPS4 is a dynamic component of the centrosome that regulates centrosome localization of $\gamma$-tubulin, centriolar satellite stability and ciliogenesis
Ott C, et al.
Scientific reports, 8(1), 3353-3353 (2018)
Lauren R Kett et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(14), 5724-5742 (2015-04-10)
Accumulating evidence from genetic and biochemical studies implicates dysfunction of the autophagic-lysosomal pathway as a key feature in the pathogenesis of Parkinson's disease (PD). Most studies have focused on accumulation of neurotoxic α-synuclein secondary to defects in autophagy as the
Aiqin Hu et al.
BMC genetics, 20(1), 7-7 (2019-01-13)
Vacuolar protein sorting-associated protein 4B (VPS4B) is a member of the ATP enzyme AAA protein family, and is mainly involved in protein degradation and cell membrane fusion. Recently, a dominant mutation in this gene was identified in human dentin dysplasia
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