추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
predicted mol wt 124 kDa
종 반응성
human
기술
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ZEB1(6935)
일반 설명
Zinc finger E-box-binding homeobox 1 (ZEB1) is an EMT (epithelial-mesenchymal transition) transcription factor. The gene encoding this protein is localized on human chromosome 10p11.2.
면역원
ZEB1 antibody was raised against a 15 amino acid peptide near the center of human ZEB1.
The immunogen is located within amino acids 530 - 580 of ZEB1.
The immunogen is located within amino acids 530 - 580 of ZEB1.
애플리케이션
Anti-ZEB1 antibody produced in rabbit has been used in western blotting.
생화학적/생리학적 작용
Zinc finger E-box-binding homeobox 1 (ZEB1) controls the expression of E-cadherin as a repressor. It plays an important role in tumor invasion and metastasis. Epigenetic suppression of ZEB1 might be a useful tool for overcoming drug resistance in human breast cancer. Mutations in this gene are associated with posterior polymorphous corneal dystrophy and Fuchs′ endothelial corneal dystrophy (FECD6).
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
결합
The action of this antibody can be blocked using blocking peptide SBP3500514.
물리적 형태
Supplied in PBS with 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.
Cellular and molecular gastroenterology and hepatology (2015)
GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.
Scientific Reports (2016)
Novel mutations in the ZEB1 gene identified in Czech and British patients with posterior polymorphous corneal dystrophy.
Human Mutation (2007)
An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer.
Oncotarget (2016)
Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation.
Investigative Ophthalmology & Visual Science (2013)
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