추천 제품
생물학적 소스
goat
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
mouse, human, rat
기술
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... APBA1(320)
일반 설명
APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) is a neuronal adaptor protein belonging to the X11 family. It consists of a centrally located phosphotyrosine binding domain which inhibits the production of Aβ peptide, two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains.
면역원
Peptide with sequence C-EASHPSQDGKRQYK from the internal region of the protein sequence according to NP_001154.2.
애플리케이션
Anti-APBA1/MINT1 antibody produced in goat is suitable for indirect ELISA and western blot analysis.
생화학적/생리학적 작용
APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) stabilizes amyloid precursor protein (APP) by directly interacting with it. It also restricts production as well as accumulation of proteolytic APP fragment in the brain of Alzheimer′s disease patients. It also suppresses glycogen synthase kinase-3β promoter activity by coupling with a silencer binding protein.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ju-Hyun Lee et al.
The Journal of biological chemistry, 278(47), 47025-47029 (2003-09-13)
Increased production and deposition of the 40-42-amino acid beta-amyloid peptide (Abeta) is believed to be central to the pathogenesis of Alzheimer's disease. Abeta is derived from the amyloid precursor protein (APP), but the mechanisms that regulate APP processing to produce
Kwok-Fai Lau et al.
Neuroreport, 21(11), 761-766 (2010-06-10)
X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal
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