추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~37.1 kDa
종 반응성
human
기술
flow cytometry: suitable
western blot: 1 μg/mL
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MRGPRX2(117194)
관련 카테고리
일반 설명
Mas-related G protein-coupled receptor X2 (MRGPRX2) belonging to the class A GPCR/Mas-related gene family is expressed in sensory neurons, mast cells, and keratinocytes. It has seven transmembrane (TM) α-helices. MRGPRX2 mRNA is found at a high level in the skin. It is also detected in adipose tissue, esophagus, urinary bladder, and lungs. MRGPRX2 gene with two-exon is mapped on human chromosome 11p15.
면역원
MRGPRX2 (NP_473371.1, 1 a.a. ~ 330 a.a) full-length human protein.
Sequence
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
Sequence
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
생화학적/생리학적 작용
Mas-related G protein-coupled receptor X2 (MRGPRX2) expressed on mast cells acts as an important receptor for pseudo-allergic responses induced by drugs. It is involved in the evolution of the human nervous system. It is also crucial to mast cells. MRGPRX2 gene mutation impairs the risk of anaphylactic actions facilitated by the MRGPRX2 receptor.
물리적 형태
Solution in phosphate buffered saline, pH 7.4
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Haihui Wu et al.
Progress in histochemistry and cytochemistry, 50(1-2), 11-17 (2015-06-25)
Mas-related genes (Mrgs) belong to a large family of G protein-coupled receptor genes found in rodents. Human MRGX proteins are G protein-coupled 7-transmembrane proteins sharing 41-52% amino acid identity with each other, but have no orthologs in rodents. MrgX2 is
Chalatip Chompunud Na Ayudhya et al.
International journal of molecular sciences, 22(10) (2021-06-03)
The neuropeptide substance P (SP) mediates neurogenic inflammation and pain and contributes to atopic dermatitis in mice through the activation of mast cells (MCs) via Mas-related G protein-coupled receptor (GPCR)-B2 (MrgprB2, human ortholog MRGPRX2). In addition to G proteins, certain
Di Wei et al.
Immunopharmacology and immunotoxicology, 43(1), 77-84 (2020-12-18)
Clozapine is one of the most widely used second-generation antipsychotics in clinic. However, allergy-like symptoms such as rash and angioedema have been reported frequently, and the mechanism is still not clear. Mas-related G protein-coupled receptor X2 (MRGPRX2) expressed on mast
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