K0265

Anti-Potassium Channel K_2P4.1 (TRAAK) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-KCNK4, Anti-TWIK-related arachidonic acid-stimulated K⁺ channel
• MDL number: MFCD09753858
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: lyophilized powder
• 종 반응성: human, rat
• 기술: immunohistochemistry: suitable; western blot: 1:200 using HEK-K_2P4.1 transfected cells or rat cerebellum lysate
• UniProt 수납 번호: Q9NYG8
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... KCNK4(50801) ; rat ... Kcnk4(116489)

설명

일반 설명

The gene K2P4.1, also referred to as KCNK4 (potassium two pore domain channel subfamily K member 4), encodes a protein belonging to the subfamily of K2P (two pore domain K⁺ channel) channels called TRAAK (TWIK-related arachidonic acid-stimulated K⁺ channel). The TRAAK channels are expressed selectively in the nervous system. TRAAK channel contains two protomers, each with two distinct pore domains forming a two-fold symmetric potassium channel.

특이성

The K_2P4.1 antibody is directed against a highly conserved epitope in the intraracellular C-terminal region of the human K_2P4.1 channel.

면역원

peptide NLAFIDESSDTQSERGC, corresponding to amino acid residues 343-359 of human K_2P4.1.

생화학적/생리학적 작용

The gene KCNK4 (potassium two pore domain channel subfamily K member 4) encodes a potassium channel that is mechanosensitive and is regulated by polyunsaturated fatty acids and temperature. The structure and chemical composition of the lipid bilayer has a profound effect on the functioning of this K⁺ channel. It is found to regulate the noxious input threshold in dorsal root ganglia neurons.

물리적 형태

Lyophilized powder from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

재구성

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein, such as BSA (1-3%).

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable