추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
147254 Da
종 반응성
human
기술
flow cytometry: 1:10-1:50
immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... PTPRC(5788)
일반 설명
Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 is expressed on T-cells and is found in multiple isoforms. The extracellular domain of the protein is predicted to have an amino-terminal mucin-like segment, a cysteine-rich domain and three fibronectin type 3 domains. The gene encoding this protein is localized on human chromosome 1q31.3.
애플리케이션
ANTI-CD45(C-TERMINAL) antibody produced in rabbit has been used in Western blotting.
생화학적/생리학적 작용
Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 acts as a protein tyrosine phosphatase in leucocyte signaling. It has a role in flow cytometric diagnostics in leukemia. By dephosphorylation of Src kinases, the protein acts as a regulator of antigen receptor signaling in T and B cells. As a negative regulator of janus kinases, CD45 inhibits cytokine receptor signaling.
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Initiation of T cell signaling by CD45 segregation at `close-contacts?
Veronica T, et al.
Nature Immunology (2016)
CD45RO+ Memory T Lymphocytes ? a Candidate Marker for TNM-Immunoscore in Squamous Non?Small Cell Lung Cancer1
Erna-Elise Paulsen, et al.
Neoplasia (2015)
High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
Gunnar Cario, et al.
Haematologica (2014)
Replication of association of the PTPRC gene with response to anti?tumor necrosis factor therapy in a large UK cohort*
Darren Plant, et al.
Arthritis & Rheumatology (Hoboken, N.J.) (2011)
Clinicoradiological characteristics, management and prognosis of primary myeloid sarcoma of the central nervous system: A report of four cases
Bao Yang, et al.
Oncology Letters (2017)
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