추천 제품
제품명
MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse, clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution
생물학적 소스
mouse
Quality Level
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
137CT26.1.1, monoclonal
양식
buffered aqueous solution
분자량
41737 Da
종 반응성
mouse, human
기술
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000
동형
IgG1κ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ACTB(60)
일반 설명
β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.
애플리케이션
Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.
생화학적/생리학적 작용
β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques
Acharya UR, et al.
International journal of biosciences, 4(11) (2014)
Sara Cuvertino et al.
American journal of human genetics, 101(6), 1021-1033 (2017-12-09)
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have
Induction of drug resistance in human hepatoma cells cultured on a silicate fiber based 3d scaffold
Mizutami T, et al.
Advances in Biochemical Engineering null
Zunshu Du et al.
Aging cell, 20(8), e13437-e13437 (2021-07-23)
Synapse degeneration correlates strongly with cognitive impairments in Alzheimer's disease (AD) patients. Soluble Amyloid-beta (Aβ) oligomers are thought as the major trigger of synaptic malfunctions. Our earlier studies have demonstrated that Aβ oligomers interfere with synaptic function through N-methyl-D-aspartate receptors
Qifeng Deng et al.
Redox biology, 49, 102217-102217 (2021-12-24)
Maintaining host iron homeostasis is an essential component of nutritional immunity responsible for sequestrating iron from pathogens and controlling infection. Nucleotide-oligomerization domain-like receptors (NLRs) contribute to cytoplasmic sensing and antimicrobial response orchestration. However, it remains unknown whether and how NLRs
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