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Merck
모든 사진(1)

Key Documents

S7817

Sigma-Aldrich

Scriptaid

≥95%, solid

동의어(들):

6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide

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About This Item

실험식(Hill 표기법):
C18H18N2O4
CAS Number:
Molecular Weight:
326.35
MDL number:
UNSPSC 코드:
12352203
PubChem Substance ID:
NACRES:
NA.77

생물학적 소스

synthetic (organic)

Quality Level

분석

≥95%

형태

solid

mp

160-161 °C

solubility

DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow
DMSO: 1 mg/mL
methanol: soluble

저장 온도

−20°C

SMILES string

ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23

InChI

1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)

InChI key

JTDYUFSDZATMKU-UHFFFAOYSA-N

일반 설명

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

애플리케이션

Scriptaid has been used in post activation of oocytes and embryo culture.
Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.5,6

생화학적/생리학적 작용

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.
Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.2 Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.3 It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.4

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

법적 정보

Sold under license of U.S. Patent No. 6,544,957.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor ?(ER) in ER negative human breast cancer cells in combination with 5-aza 2?-deoxycytidine
Keen JC, et al.
Breast Cancer Research and Treatment, 81(3), 177-186 (2003)
Weihua Xu et al.
PloS one, 8(5), e64705-e64705 (2013-06-07)
Somatic cell nuclear transfer (SCNT) in mammalian cloning currently remains inefficient. Incomplete or erroneous epigenetic reprogramming of specialized donor somatic nuclear and resulting aberrant gene expression during development of cloned embryos is commonly believed as the main reason that causes
Effects of combined treatment of MG132 and scriptaid on early and term development of porcine somatic cell nuclear transfer embryos
Mao J, et al.
Cellular Reprogramming, 14(5), 385-389 (2012)
J Johnson et al.
Cellular and molecular biology (Noisy-le-Grand, France), 51(2), 229-238 (2005-09-21)
Many different classes of drugs induce fetal hemoglobin (HbF) including histone deacetylase (HDAC) inhibitors such as butyrate and trichostatin A. Although these agents induce gamma-globin expression in culture many are ineffective in vivo, therefore research efforts continue to identify clinically
Kiho Lee et al.
Molecular reproduction and development, 80(2), 145-154 (2012-12-15)
In general, pig embryos established by somatic cell nuclear transfer (SCNT) are transferred at the one-cell stage because of suboptimal embryo culture conditions. Improvements in embryo culture can increase the practical application of late embryo transfer. The goal of this

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