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Merck
모든 사진(2)

주요 문서

S4813

Sigma-Aldrich

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit

buffered aqueous solution, IgG fraction of antiserum

동의어(들):

Anti-SNTA1

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

IgG fraction of antiserum

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen 60 kDa

종 반응성

rat

기술

immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle
microarray: suitable
western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

mouse ... Snta1(20648)
rat ... Snta1(362242)

일반 설명

α1-syntrophin (SNTA1) is a dystrophin-associated protein, that has four domains- a postsynaptic density protein-95/disc large/zona occludens-1 (PDZ) domain, two pleckstrin homology (PH1 and PH2) domains and a syntrophin unique (SU) domain. It is located on human chromosome 20q11.2. It is usually present in the peripheral cytoplasmic membrane.
Anti-α1-Syntrophin (RA-16) is developed in rabbit using a synthetic peptide corresponding to a sequence of mouse α1-syntrophin The syntrophins are a family of intracellular peripheral membrane proteins (58-60 kDa), comprising at least three isoforms α1, β1, and β2-syntrophins. Syntrophins in mammalian skeletal muscle have been shown to be part of a complex of proteins associated with dystrophin, the product of Duchenne/Becker muscular dystrophy gene. The C-terminal 57 amino acids region of syntrophins is highly conserved among the three isoforms, and may contain the binding site for dystrophin.

면역원

synthetic peptide corresponding to a sequence of mouse α1-syntrophin (amino acids 191-206 with N-terminally added lysine) conjugated to KLH.

애플리케이션

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.

생화학적/생리학적 작용

α1-Syntrophin recruit signaling proteins(2) to the membrane via association with the dystrophin complex.
α1-syntrophin (SNTA1) mutations results in LQTS (cardiac channelopathies like long QT syndrome). It modulates the development of adipocyte lipid droplet. It also participates in the survival signaling pathway in myoblasts. α1-syntrophin controls voltage-gated Na+ channels. It acts as a substrate for stress-activated protein kinase-3 (SAPK-3).

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current
Cheng J, et al.
Circulation. Arrhythmia and Electrophysiology, 2(6), 667-676 (2009)
?1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current
Choi JI, et al.
PLoS ONE, 11(3) (2016)
?-Syntrophin is involved in the survival signaling pathway in myoblasts under menadione-induced oxidative stress
Lim JA, et al.
Experimental Cell Research, 344(1), 1-10 (2016)
The adaptor protein alpha-syntrophin regulates adipocyte lipid droplet growth
Eisinger K, et al.
Experimental Cell Research, 345(1), 100-107 (2016)
Clinical utility gene card for: long-QT syndrome (types 1-13)
Beckmann BM, et al.
European Journal of Human Genetics, 21(10) (2013)

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