S2812
SNC80
≥98% (HPLC), solid
동의어(들):
(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, SNC 80, SNC-80
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C28H39N3O2
CAS Number:
Molecular Weight:
449.63
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
![[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/227/014/768064c2-9ae6-47bd-8550-e2aa5c3b61de/640/768064c2-9ae6-47bd-8550-e2aa5c3b61de.png)
![[D-Ala2, D-Leu5]-Enkephalin acetate salt ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/934/176/d990e568-42df-43e9-a231-da7a3d9d7687/640/d990e568-42df-43e9-a231-da7a3d9d7687.png)
Quality Level
분석
≥98% (HPLC)
양식
solid
색상
off-white
solubility
DMSO: soluble
SMILES string
CCN(CC)C(=O)c1ccc(cc1)[C@H](N2C[C@H](C)N(CC=C)C[C@H]2C)c3cccc(OC)c3
InChI
1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27?/m0/s1
InChI key
KQWVAUSXZDRQPZ-QNWUEUMSSA-N
유전자 정보
human ... OPRD1(4985)
mouse ... Oprd1(18386)
rat ... Oprd1(24613) , Oprm1(25601)
애플리케이션
Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.5
생화학적/생리학적 작용
SNC80 is a δ opioid receptor agonist.
SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4
특징 및 장점
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Richard M van Rijn et al.
The Journal of pharmacology and experimental therapeutics, 335(1), 133-139 (2010-07-08)
Alcoholism and anxiety disorders have a huge impact on society and afflict 17.6 million and 40 million people in the United States, respectively. A strong comorbidity exists between alcoholism and anxiety disorders. Indeed, alcohol withdrawal-induced anxiety is a primary contributing
Matthew D Metcalf et al.
ACS chemical neuroscience, 3(7), 505-509 (2012-08-04)
Coexpressed and colocalized μ- and δ-opioid receptors have been established to exist as heteromers in cultured cells and in vivo. However the biological significance of opioid receptor heteromer activation is less clear. To explore this significance, the efficacy of selective
Matthew L Banks et al.
Psychopharmacology, 216(3), 431-439 (2011-03-04)
Delta-opioid agonists enhance the antinociceptive efficacy of methadone and other mu-opioid agonists. However, relatively little is known about the degree to which delta agonists might enhance the abuse-related effects of mu agonists. This study used a behavioral economic approach to
Paul Chu Sin Chung et al.
Behavioural brain research, 278, 429-434 (2014-12-03)
The delta opioid receptor (DOR) has raised much interest for the development of new therapeutic drugs, particularly to treat patients suffering from mood disorders and chronic pain. Unfortunately, the prototypal DOR agonist SNC80 induces mild epileptic seizures in rodents. Although
Katia Befort et al.
Psychopharmacology, 214(4), 967-976 (2010-12-25)
Response inhibition, a primary symptom of many psychiatric disorders, is mediated through a complex neuropharmacological network that involves dopamine, serotonin, glutamate, noradrenaline, and cannabinoid mechanisms. Recently, we identified an opioidergic contribution to response inhibition by showing that deletion of mu
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