추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
종 반응성
rat
기술
western blot: 1:200 using rat heart membranes
UniProt 수납 번호
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SCN5A(6331)
mouse ... Scn5a(20271)
rat ... Scn5a(25665)
관련 카테고리
일반 설명
SCN5A (sodium voltage-gated channel α subunit 5) codes for an α subunit of the cardiac sodium channel (NaV1.5). It is located on human chromosome 3p22.2.
면역원
peptide corresponding to amino acid residues 493-511 of rH1 (Accession P15389). This epitope is identical in mouse and highly homologous in human (17/19 residues identical).
애플리케이션
Anti-Sodium Channel NaV1.5 antibody produced in rabbit has been in immunoblotting and immunofluorescence.
생화학적/생리학적 작용
SCN5A (sodium voltage-gated channel α subunit 5) regulates the movement of sodium ions into cells, which helps in the production and diffusion of electrical impulses. SCN5A mutations results in the loss or gain of sodium channel activity and cause several cardiac diseases like Brugada syndrome, Long QT syndrome type 3, Sick sinus syndrome and progressive familial heart block.
물리적 형태
Lyophilized at ~0.8 mg/mL in phosphate buffered, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Na v1.4 and Na v1.5 are modulated differently during muscle immobilization and contractile phenotype conversion
Rannou F, et al.
Journal of Applied Physiology, 111(2), 495-507 (2011)
Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice
Gonzalez JP, et al.
Scientific Reports, 5 (2015)
Hiroki Takanari et al.
Cardiovascular research, 111(4), 410-421 (2016-07-01)
In healthy hearts, ventricular gap junctions are mainly composed by connexin43 (Cx43) and localize in the intercalated disc, enabling appropriate electrical coupling. In diseased hearts, Cx43 is heterogeneously down-regulated, whereas activity of calmodulin/calcium-calmodulin protein kinase II (CaM/CaMKII) signalling increases. It
Liang Guo et al.
Toxicological sciences : an official journal of the Society of Toxicology, 123(1), 281-289 (2011-06-23)
Improved in vitro systems for predicting drug-induced toxicity are needed in the pharmaceutical and biotechnology industries to decrease late-stage drug attrition. One unmet need is an early screen for cardiotoxicity, which accounts for about one third of safety-based withdrawn pharmaceuticals.
Exome Sequencing Identifies Compound Heterozygous Mutations in SCN5A Associated with Congenital Complete Heart Block in the Thai Population
Thongnak C, et al.
Disease Markers (2016)
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