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Merck
모든 사진(3)

Key Documents

S0532

Sigma-Aldrich

Strychnine

동의어(들):

(−)-Strychnine

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About This Item

실험식(Hill 표기법):
C21H22N2O2
CAS Number:
Molecular Weight:
334.41
Beilstein:
52979
EC Number:
MDL number:
UNSPSC 코드:
12352210
PubChem Substance ID:
NACRES:
NA.54

mp

284-286 °C (lit.)

solubility

chloroform: soluble, clear to hazy

SMILES string

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

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일반 설명

Strychnine is a colorless, odourless and bitter tasting powder. It is absorbed in skin, gastrointestinaland respiratory tract. Strychnine generates oxides of nitrogen and carbon on decomposition.
Strychnine is a glycine receptor antagonist not associated with the N-methyl-D-aspartate (NMDA) receptor. It is an alkaloid extracted from Strychnos nux vomica seeds.

애플리케이션

Strychnine has been used as a glycine receptors antagonist in hippocampal CA1 pyramidal and rostral ventromedial medulla (RVM) neurons. It has also been used as type C glycine receptor antagonist in direction selective (DS) retinal cells.
Strychnine has been used in antagonist profiling to characterize a novel nicotinic receptor in Aplysia neuroendocrine cells.

생화학적/생리학적 작용

At low doses, strychnine is used for circulatory problems, gastrointestinal disorders and eye diseases.
Strychnine is used as a rodenticide and a glycine receptor antagonist, which inhibits Renshaw cell-motor neuron synapse. It binds to the α subunit N-terminal region of the glycine receptor. The effect of strychnine is neutralized in the presence of glycine receptor agonist ivermectin. Strychnine also inhibits leukocyte motility.
Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

픽토그램

Skull and crossbonesEnvironment

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

Spatiotemporally asymmetric excitation supports mammalian retinal motion sensitivity
Matsumoto A, et al.
Current Biology, 29(19) (2019)
In vivo protection against strychnine toxicity in mice by the glycine receptor agonist ivermectin
Maher A, et al.
BioMed Research International (2014)
Glycine-gated chloride channels in neutrophils attenuate calcium influx and superoxide production
WHEELER M, et al.
Faseb Journal, 14(3), 476-484 (2000)
A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins
Franccois A, et al.
Neuron, 93(4), 822-839 (2017)
Preparation of molecularly imprinted polymers for strychnine by precipitation polymerization and multistep swelling and polymerization and their application for the selective extraction of strychnine from nux-vomica extract powder.
Nakamura Y
Journal of Separation Science, 39(8), 1542-1550 (2016)

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