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Merck
모든 사진(1)

주요 문서

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S009

Sigma-Aldrich

LY-165,163

solid

동의어(들):

4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, PAPP

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C19H22F3N3
CAS Number:
1814-64-8
Molecular Weight:
349.39
MDL number:
MFCD00055098
UNSPSC 코드:
12352202
PubChem Substance ID:
24278123
NACRES:
NA.77

양식

solid

Quality Level

100

색상

off-white

solubility

0.1 M HCl: slightly soluble
H2O: insoluble
ethanol: freely soluble

SMILES string

Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1

InChI

1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

InChI key

GAAKALASJNGQKD-UHFFFAOYSA-N

유전자 정보

human ... HTR1A(3350) , HTR1D(3352)

생화학적/생리학적 작용

Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
038H4680

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문서 라이브러리 방문

R W Fuller et al.
The Journal of pharmacology and experimental therapeutics, 239(2), 454-459 (1986-11-01)
1-(m-Trifluoromethylphenyl)-4-(p-aminophenylethyl)piperazine (LY 156163), reported previously to have selective affinity for the 5-HT1A subtype of serotonin receptor in vitro, was studied at doses of 1.25 to 20 mg/kg i.p. in rats to determine if it had properties characteristic of centrally acting
R B McCall et al.
The Journal of pharmacology and experimental therapeutics, 242(3), 1152-1159 (1987-09-01)
Previous studies indicate that serotonin (5-HT) neurons provide a tonic excitatory input to central sympathetic neurons. The purpose of the present study was to utilize a number of 5-HT agonists in order to provide insights into the general function of
P H Hutson et al.
European journal of pharmacology, 138(2), 215-223 (1987-06-19)
1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY 165163, PAPP) (1 mg/kg s.c.) significantly decreased 5-hydroxytryptophan (5-HTP) accumulation in cortex, hippocampus, striatum, septum, pons + medulla and midbrain and increased DOPA accumulation in the cortex and striatum following inhibition of aromatic amino acid decarboxylase with NSD
M De Vivo et al.
Biochemical pharmacology, 40(7), 1551-1558 (1990-10-01)
5-Hydroxytryptamine (serotonin, 5-HT) stimulates basal adenylyl cyclase activity in membranes from guinea pig or rat hippocampi, but 5-HT inhibits forskolin-stimulated adenylyl cyclase activity in these same membranes. The opposing effects of 5-HT on adenylyl cyclase activity indicate that distinct 5-HT
M L Cohen et al.
Life sciences, 38(1), 1-5 (1986-01-06)
The nature of the receptor mediating serotonin contraction in the rat stomach fundus has not been clearly associated with either 5HT1 or 5HT2 receptors. We have explored the possibility that such receptors in the rat fundus may better correlate with
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