추천 제품
종 반응성
human
포장
kit of 96 wells (12 strips x 8 wells)
기술
ELISA: suitable
입력
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/ml
검출 방법
colorimetric
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... NELL1(4745)
일반 설명
The NELL-1 (neural EGFL like 1) gene encodes an extracellular glycoprotein and is mapped to human chromosome 11p15. Nell-1 is a 810 amino acids protein containing thrombospondin-1 module at its N-terminus and includes other motifs : five von Willebrand factor C domains and six epidermal growth factor (EGF)-like domains.
This ELISA antibody pair detects human NELL-1. Other species are not determined.
애플리케이션
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
생화학적/생리학적 작용
NELL-1 (neural EGFL like 1) is associated with the risk of Rhabdomyosarcomas and the gene is identified to be hypomethylated. The protein encoded influences osteogenic related processes and thus loss of the NELL-1 gene function leads to abnormality in bone and cartilage. NELL-1 is considered as a essential factor in skeletal development as it controls the action of runt-related transcription factor 2. Lack of Nell-1 protein decreases the expression of gene encoding cartilage proteins such as collagens, tenascins, matrilins, and chondroadherin. It serves as an important growth factor in promoting regeneration of articular cartilage. NELL-1 is a tumor suppressor gene and hypermethylation of its promoter region indicates poor prognosis of the disease in esophageal adenocarcinoma.
기타 정보
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Accelerated chondrogenic differentiation of human perivascular stem cells with NELL-1.
Li C S, et al.
Tissue Engineering: Part A, 22(3-4), 272-285 (2016)
MALDI-TOF mass array analysis of Nell-1 promoter methylation patterns in human gastric cancer.
Gao C, et al.
BioMed Research International, 2015 (2015)
Novel Wnt regulator NEL-like molecule-1 antagonizes adipogenesis and augments osteogenesis induced by bone morphogenetic protein 2.
Shen J, et al.
The American Journal of Pathology, 186(2), 419-434 (2016)
NELL1, whose high expression correlates with negative outcomes, has different methylation patterns in alveolar and embryonal rhabdomyosarcoma.
Tombolan L, et al.
Oncotarget, 8(20), 33086-33086 (2017)
Ritsuko Nakamura et al.
Cancer science, 106(5), 656-664 (2015-03-03)
Neural epidermal growth factor-like like (NELL) 1 and 2 constitute a family of multimeric and multimodular extracellular glycoproteins. Although the osteogenic effects of NELL1 and functions of NELL2 in neural development have been reported, their expression and functions in cancer
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