RAB1574

Human Matriptase ELISA

for serum, plasma and cell culture supernatants

• UNSPSC 코드: 41116158
• NACRES: NA.32

속성

• 종 반응성: human
• 포장: kit of 96 wells (12 strips x 8 wells)
• 기술: ELISA: suitable
• 입력: sample type plasma; sample type cell culture supernatant(s); sample type serum
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 0.41 ng/mL; standard curve range: 0.410-100 ng/mL
• 검출 방법: colorimetric
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... ST14(6768)

설명

일반 설명

The ST14 (suppression of tumorigenicity 14) gene encodes a cell surface serine protease which is also called as matriptase. The ST14 gene is mapped to human chromosome 11q24.3.

This ELISA antibody pair detects Human Matriptase. Other species not yet determined.

애플리케이션

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

생화학적/생리학적 작용

St14 (suppression of tumorigenicity 14) forms complexes with serine proteases inhibitors HAIs (hepatocyte growth factor activator inhibitors), to prevent its proteolytic activity. ST14 expression is required for epithelial mesenchymal transition in tumor cells. St14′s biological activity is specific to different substrates, which includes extracellular matrix proteins, hepatocyte growth factor, epidermal growth factor receptor (EGFR), adhesion molecules including Mac25 (insulin-like growth factor-binding protein 7) and Tie2 (angiopoietin-1 receptor) , proteases including urokinase plasminogen activator (uPA), prostasin (PRSS8), matrix metalloprotease 3 (MMP3). Upregulation of the gene is found in progressed epithelial cancer but lower expression of the gene is observed in colon cancer and hence it is termed ‘suppression of tumors′.

기타 정보

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

안전성 정보

• 픽토그램: GHS05
• 신호어: Warning
• 유해 및 위험 성명서: H290
• 예방조치 성명서: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable