추천 제품
종 반응성
mouse
포장
kit of 96 wells (12 strips x 8 wells)
기술
ELISA: suitable
입력
sample type cell culture supernatant(s)
sample type plasma
sample type serum sample(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1.5 pg/ml
검출 방법
colorimetric
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
mouse ... Epo(13856)
일반 설명
This ELISA antibody pair detects Mouse Erythropoietin (EPO)
애플리케이션
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
생화학적/생리학적 작용
Erythropoietin (EPO) is a glycoprotein hormone which is essential for the proliferation of erythropoietic progenitors to produce red blood cells (RBCs). Peritubular fibroblast in kidney cortex is the primary site for EPO production in adults, though spleen, bone marrow and liver contribute to the production. In fetus, liver is the primary site for EPO production. Additionally, EPO functions in some cytoprotective activities like, antiapoptotic, antioxidant, and anti-inflammatory responses. Hypoxia inducible factors upregulate EPO expression. EPO expression increases with decreased hemoglobin concentration in few cases of anemia. Decreased production of EPO is the cause of anemia in chronic kidney diseases. Circulating endogenous antibodies to EPO (anti-EPO) is the cause of anemia in multiple diseases like human immunodeficiency virus (HIV) infection, hepatitis C virus infection, systemic lupus erythematosus. Gain-of-function polymorphism in EPO causes familial erythrocytosis.
기타 정보
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia
Hepatobiliary & Pancreatic Diseases International : HBPD INT, 16(3), 289-295 (2017)
Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells
Archives of Biochemistry and Biophysics, 636, 11-16 (2017)
Physiology and pharmacology of erythropoietin
Transfusion Medicine and Hemotherapy : Offizielles Organ der Deutschen Gesellschaft Fur? Transfusionsmedizin und Immunham?atologie, 40(5), 302-309 (2013)
A Gain-of-Function Mutation in EPO in Familial Erythrocytosis
The New England Journal of Medicine, 378(10), 924-930 (2018)
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