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Merck
모든 사진(2)

주요 문서

RAB0472

Sigma-Aldrich

Human TIMP-2 ELISA Kit

for serum, plasma, cell culture supernatant and urine

동의어(들):

Metalloproteinase inhibitor 2 , TIMP-2, Tissue inhibitor of metalloproteinases 2

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모든 사진(2)

About This Item

UNSPSC 코드:
41116158
NACRES:
NA.32

종 반응성

human

포장

kit of 96 wells (12 strips x 8 wells)

기술

ELISA: suitable
capture ELISA: suitable

입력

sample type urine
sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2 pg/mL
standard curve range: 1.6-1200 pg/mL

검출 방법

colorimetric

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... TIMP2(7077)

일반 설명

The Human TIMP-2 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human TIMP-2 in serum, plasma, cell culture supernatants and urine.

면역원

Recombinant Human TIMP2

애플리케이션

For research use only. Not for use in diagnostic procedures.
Human TIMP-2 ELISA Kit has been used to measure tissue inhibitor of metalloproteinase-2 (TIMP-2) level in blood samples from Atherosclerotic renal artery stenosis (ARAS) patients.

생화학적/생리학적 작용

Tissue inhibitor of metalloproteinase-2 (TIMP-2) plays a vital role in inhibition of matrix metalloproteinases (MMPs) and functions as a key modulator of extracellular matrix deposition and degradation in various physiological processes. TIMP-2 can also act through a matrix metalloproteinase (MMP)-independent mechanism inhibiting endothelial cell proliferation in vitro. TIMP-2 mediates anti-angiogenic activities in vivo. TIMP-2 is a target gene of the microRNA-miR-22. TIMP-2 functions as a biomarker for cell cycle arrest.

기타 정보

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

키트 구성품 역시 별도로 이용 가능함

제품 번호
설명
SDS
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

픽토그램

Corrosion
GHS05

신호어

Warning

유해 및 위험 성명서

H290

예방조치 성명서

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

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시험 성적서(COA)

Lot/Batch Number
0721B0192
0508K0192
0628I0192
0308I0192
0929H0192

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COA 검색

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문서 라이브러리 방문

Atherosclerotic renal artery stenosis is associated with elevated cell cycle arrest markers related to reduced renal blood flow and postcontrast hypoxia.
Saad A
Nephrology, Dialysis, and Transplantation, 31(11), 1855-1863 (2016)
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
Gomez DE
European Journal of Cell Biology, 74(2), 111-122 (1997)
Changes in inflammatory biomarkers after renal revascularization in atherosclerotic renal artery stenosis.
Wang W
Nephrology, Dialysis, and Transplantation, 31(9), 1437-1443 (2016)
TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism.
Seo DW
Cell, 114(2), 171-180 (2003)
A Eirin et al.
Acta physiologica (Oxford, England), 226(3), e13267-e13267 (2019-02-26)
Patients with renovascular hypertension (RVH) exhibit elevated urinary mtDNA copy numbers, considered to constitute surrogate markers of renal mitochondrial injury. The modest success of percutaneous transluminal renal angioplasty (PTRA) in restoring renal function in RVH has been postulated to be
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