RAB0219

Human sICAM1 ELISA Kit

for serum, plasma, cell culture supernatant and urine

• UNSPSC 코드: 41116158
• NACRES: NA.32

속성

• 종 반응성: human
• 포장: kit of 96 wells (12 strips x 8 wells)
• 기술: ELISA: suitable; capture ELISA: suitable
• 입력: sample type urine; sample type plasma; sample type serum; sample type cell culture supernatant(s)
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 150 pg/mL; standard curve range: 0.313-20 ng/mL
• 검출 방법: colorimetric
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... ICAM1(3383)

설명

일반 설명

The Human sICAM-1 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human soluble ICAM-1 in serum, plasma, cell culture supernatants and urine.

면역원

Recombinant Human ICAM1

애플리케이션

For research use only. Not for use in diagnostic procedures.
Human sICAM1 (intercellular adhesion molecule 1) ELISA Kit has been used for measuring sICAM1 levels in the endothelial cell-conditioned medium.

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

생화학적/생리학적 작용

The expression of ICAM1 (intercellular adhesion molecule 1) is strongly increased by Interleukin-1 (IL-1) and interferon (IFN)-γ. It is expressed on lymphoid cells where it is required for phorbol ester-induced aggregation. It participates in LFA-1-dependent NK cell stimulation through its attachment to actin cytoskeleton through α-actinin or ezrin. It also acts as the receptor for rhinovirus, a common cold virus, and Plasmodium falciparum. Soluble ICAM-1 (sICAM1) levels are elevated in pregnant women with gestational diabetes mellitus (GDM), which is an outcome of endothelial cell activation and dysfunction. In addition, ICAM-1 also has an essential role in binding circulating leukocytes to the blood vessel wall and trans-endothelial migration to vascular intima. Meta-analysis of case-control studies show that rs1799969 polymorphism in ICAM-1 gene is linked with increased susceptibility to cancer. sICAM1 might act as a biomarker for unipolar and bipolar patients.

기타 정보

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

키트 구성품 역시 별도로 이용 가능함

• RABELADA ELISA 1X Assay/Sample Diluent Buffer A (Item D1)
• RABELADB ELISA 5X Assay/Sample Diluent Buffer B (Item E1)
• RABSTOP3 ELISA Stop Solution (Item I)
• RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
• RABWASH4 20X Wash Buffer (Item B)

안전성 정보

• 픽토그램: GHS05
• 신호어: Warning
• 유해 및 위험 성명서: H290
• 예방조치 성명서: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class Code: 8A - Combustible corrosive hazardous materials