RAB0166

Phospho-EGFR (pTyr¹⁰⁶⁸) and pan-EGFR ELISA Kit

for detection of human phospho-egfr (pTyr¹⁰⁶⁸) and pan-egfr in cell and tissue lysates

• UNSPSC 코드: 41116158
• NACRES: NA.32

속성

• 종 반응성: human
• 포장: kit of 96 wells (12 strips x 8 wells)
• 기술: ELISA: suitable; capture ELISA: suitable
• 입력: sample type: human cell lysate; sample type: human tissue lysate
• 검출 방법: colorimetric
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... EGFR(1965)

설명

일반 설명

The Phospho-EGFR (pTyr¹⁰⁶⁸) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

면역원

EGFR (pTyr¹⁰⁶⁸) synthetic phosphopeptide, Recombinant Human EGFR

애플리케이션

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

생화학적/생리학적 작용

EGFR (epidermal growth factor receptor) functions as a receptor for EGF-family of proteins, which are peptide growth factors. This receptor-ligand system is also involved in the pathogenesis and progression of various types of carcinomas. In cancer, EGFR pathways promotes cellular proliferation, angiogenesis, metastasis and apoptosis. The microRNA miR-218-5p interacts with and controls EGFR, and in non-small cell lung cancer (NSCLC), the levels of EGFR are inversely related to miR-218-5p. miR-218-5p inhibits proliferation and migration of lung cancer cells by binding with EGFR, and thus, has potential in future NSCLC therapies. Phospho-EGFR activates phospho-Akt pathway in invasive bladder cancer (BC) and it can be considered as a promising therapeutic target for cancer.

기타 정보

Phosphorylated and pan protien can both be measured , in one experimnet.

안전성 정보

• 픽토그램: GHS05
• 신호어: Warning
• 유해 및 위험 성명서: H290
• 예방조치 성명서: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class Code: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable