R1903
RS 102895 hydrochloride
≥98% (HPLC), powder
동의어(들):
1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C21H21F3N2O2 · HCl
Molecular Weight:
426.86
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.32
추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
분자량
426.86 g/mol
포장
pkg of 5 mg
저장 조건
desiccated
색상
white
solubility
DMSO: >10 mg/mL
저장 온도
20-25°C
SMILES string
Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1
InChI
1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
InChI key
KRRISOFSWVKYBF-UHFFFAOYSA-N
일반 설명
RS 102895 hydrochloride is a small molecule antagonist of C-C motif chemokine receptor 2 (CCR2) which belongs to the spiropiperidine (SP) class.
애플리케이션
RS 102895 hydrochloride has been used in bromodeoxyuridine (5-bromo-2′-deoxyuridine, BrdU) cell proliferation assay to study effect of IL33 (interleukin 33) on decidual stromal cell proliferation in present of the antagonist and to study the effects of antagonists on the accumulation of bone marrow-derived microglia.
생화학적/생리학적 작용
RS 102895 hydrochloride has a high affinity to the β subunit of the C-C motif chemokine receptor 2 (CCR2) and binds specifically to it. This results in the inhibition of CCR2 signaling. It also suppresses monocyte recruitment. Hence, RS 102895 may be useful for obstructing the immune suppressive effects of monocytes during early vaccine responses.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle.
Mirzadegan T
The Journal of Biological Chemistry, 275(33), 25562-25571 (2000)
Suppression of bone marrow-derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice.
Sawada A, Niiyama Y, Ataka K, et al.
Pain, 155(9), 1762-1772 (2014)
Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity.
Mitchell LA
International Immunopharmacology, 15(2), 357-363 (2013)
Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice.
Ataka K
PLoS ONE, 8(11), e81744-e81744 (2013)
IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-?B and ERK1/2 signaling.
Hu WT
Molecular Human Reproduction, 20(4), 358-372 (2014)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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