227016
CCR2 Antagonist
≥97% (racemic mixture, HPLC), solid, CCR2 antagonist, Calbiochem®
동의어(들):
CCR2 Antagonist, 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C28H34F3N5O4S
CAS Number:
Molecular Weight:
593.66
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
product name
CCR2 Antagonist, The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
Quality Level
분석
≥97% (racemic mixture, HPLC)
형태
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
protect from light
색상
white
solubility
ethanol: 6 mg/mL
DMSO: 60 mg/mL
배송 상태
ambient
저장 온도
2-8°C
일반 설명
A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
포장
Packaged under inert gas
경고
Toxicity: Standard Handling (A)
제조 메모
Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Cherney, R.J., et al. 2008. J. Med. Chem.51, 721.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Li-Ling Wu et al.
Hepatology (Baltimore, Md.), 69(6), 2364-2380 (2019-01-21)
To understand the mechanism(s) of age-dependent outcomes of hepatitis B virus (HBV) infection in humans, we previously established an age-related HBV mouse model in which 6-week-old (N6W) C3H/HeN mice exhibited virus tolerance whereas 12-week-old (N12W) counterparts presented virus clearance. By
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