PZ0316
PF-06651600
≥98% (HPLC)
동의어(들):
1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate, PF 06651600
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C15H19N5O · C3H4O4
CAS Number:
Molecular Weight:
389.41
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
H2O: 5 mg/mL, clear (warmed)
저장 온도
room temp
SMILES string
C[C@@H]1N(C(C=C)=O)C[C@H](NC2=NC=NC3=C2C=CN3)CC1.OC(CC(O)=O)=O
InChI
1S/C15H19N5O.C3H4O4/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15;4-2(5)1-3(6)7/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19);1H2,(H,4,5)(H,6,7)/t10-,11+;/m0./s1
InChI key
QMPMPSGDPRHZCG-VZXYPILPSA-N
생화학적/생리학적 작용
PF-06651600 is a potent and selective JAK3 inhibitor.
PF-06651600 specifically targets the ATP (adenosine triphosphate)-binding domain of JAK3 (Janus kinase 3). Loss of function of JAK3 is associated with severe combined immunodeficiency syndrome.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors.
Welsch K, et al.
European Journal of Immunology, 47(7), 1096-1107 (2017)
Jak3 deficiency blocks innate lymphoid cell development.
Robinette M L, et al.
Mucosal Immunology, 11(1), 50-50 (2018)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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