PLA0259

Rabbit anti-RuvBL2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• 동의어(들): 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, 51-KD, CGI-46, ECP-51, ECP51, INO80 complex subunit J, INO80J, RVB2, Reptin 52, Reptin52, RuvB (E coli homolog)-like 2, RuvB-like 2 (E. coli), TAP54-beta, TIH2, TIP48, TIP49b, TIP60-associated protein 54-beta, erythrocyte cytosolic protein, repressing pontin 52, reptin, reptin52 protein
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity purified immunoglobulin
• 항체 생산 유형: primary antibodies
• Grade: Powered by Bethyl Laboratories, Inc.
• 종 반응성: human, mouse
• 기술: immunohistochemistry: 1:500- 1:2,000; immunoprecipitation (IP): 5-15 μg/mg; western blot: 1:2,000- 1:10,000
• 수납 번호(accession number): NP_006657.1
• UniProt 수납 번호: Q9Y230
• 배송 상태: wet ice

설명

일반 설명

RuvB-like 2 (RUVBL2), a transcription factor, belongs to the AAA+ protein subfamily of conserved ATPases linked with diverse cellular functions. A distinctive domain II (DII) protrudes from one side of the hexamer and defines two separate faces of the ring in RUVBL2.

면역원

The epitope recognized by PLA0259 maps to a region between residue 1 and 50 of human RuvB-like 2 using the numbering given in entry NP_006657.1 (GeneID 10856).

생화학적/생리학적 작용

RuvB-like 2 (RUVBL2) plays a regulatory role in the Fanconia anemia (FA) pathway, the assembly of the telomerase holoenzyme, and nonsense-mediated mRNA decay (NMD). It may play a role in tumorigenesis and cancer progression. Overexpression of the RUVBL2 protein is observed in hepatocellular carcinoma (HCC), renal cell carcinoma, colorectal cancer, gastric cancer, breast cancer, and salivary gland cancer. It can be used as a promising target for preventing and treating HCC.

물리적 형태

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

기타 정보

RuvB-like 2 (RuvBL2) is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this protein has both ATPase and DNA helicase activities [taken from NCBI Entrez Gene (GeneID: 9400)].

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable