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Merck
모든 사진(1)

Key Documents

PLA0144

Sigma-Aldrich

Rabbit anti-TRF2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

동의어(들):

TRBF2, TRF2, TTAGGG repeat-binding factor 2, telomeric DNA-binding protein, telomeric repeat binding protein 2

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

항체 형태

affinity purified immunoglobulin

항체 생산 유형

primary antibodies

Grade

Powered by Bethyl Laboratories, Inc.

종 반응성

human

기술

immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000

수납 번호(accession number)

NP_005643.1

배송 상태

wet ice

저장 온도

2-8°C

유전자 정보

rabbit ... TRF2(7014)

일반 설명

The telomeric repeat binding factor 2 (TRF2 ) gene codes for a component of shelterin. The encoded protein is dimer containing four domains : B domain at the N-terminal, the TRF homology domain, the hinge domain and the MYB/SANT (proto-oncogene, transcription factor telobox) domain at C-terminal.

면역원

The epitope recognized by PLA0144 maps to a region between residue 375 and 425 of human Telomeric Repeat Binding Factor 2 using the numbering given in entry NP_005643.1 (GeneID 7014).

생화학적/생리학적 작용

TRF2 (telomeric repeat binding factor 2) is responsible for telomere stability by the insertion of the 3′ overhang. TRF2 offers protection to DNA from being wrongly recognized by the DNA damage repair systems. Loss of TRF2 function induces DNA repair system resulting in apoptosis by causing cell cycle arrest. Upregulation of the TRF2 gene is observed in cancer and thus concluded to contribute to tumor progression.

물리적 형태

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

기타 정보

Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that localizes at chromosome ends during all phases of the cell cycle and binds directly to TTAGGG repeats. TRF2 functions to protect telomeres as being perceived as sites of DNA damage. TRF2 interacts with several proteins at telomeres, such as Rap1, Mre11, Rad50, and NBS1.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2.
Wu M, et al.
Scientific Reports, 6, 36045-36045 (2016)
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma.
Benhamou Y, et al.
Oncotarget, 7(28), 44236-44236 (2016)
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
Picco V, et al.
Oncotarget, 7(29), 46615-46615 (2016)
Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters.
Chen W, et al.
BioMed Research International, 2017, 9764752-9764752 (2017)

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