P8953

Platelet-Derived Growth Factor from porcine platelets

≥97% (SDS-PAGE and N-terminal analysis), lyophilized powder, suitable for cell culture

• 동의어(들): PDGF
• MDL number: MFCD00166903
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 제품명: Platelet-Derived Growth Factor from porcine platelets, PDGF, lyophilized powder, suitable for cell culture
• 생물학적 소스: Porcine
• Quality Level: 200
• 분석: ≥97% (SDS-PAGE and N-terminal analysis)
• 양식: lyophilized powder
• 효능: 39.00 ng/mL EC₅₀
• 품질: endotoxin tested
• 분자량: glycoprotein 38 kDa
• 포장: pkg of 5 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 기술: cell culture | mammalian: suitable
• 불순물: ≤1 EU/μg
• 색상: white
• UniProt 수납 번호: P20034
• 저장 온도: −20°C
• 유전자 정보: pig ... PDGFB(100626465)

설명

애플리케이션

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

생화학적/생리학적 작용

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

분석 메모

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)