P5057

Paromomycin sulfate salt

powder, suitable for cell culture, BioReagent

• 실험식(Hill 표기법): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• CAS Number: 1263-89-4
• Molecular Weight: 615.63 (free base basis)
• Beilstein: 5715182
• UNSPSC 코드: 12352207
• PubChem Substance ID: 24898585
• NACRES: NA.76

속성

• product name: Paromomycin sulfate salt, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg
• 제품 라인: BioReagent
• Quality Level: 200
• 형태: powder
• 효능: ≥675 μg per mg
• 기술: cell culture | mammalian: suitable
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: protein synthesis | interferes
• SMILES string: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• InChI key: OYJABWUHUYVDMJ-UDXJMMFXSA-N

설명

일반 설명

Chemical structure: aminoglycoside

Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

애플리케이션

• Paromomycin sulfate salt has been used as a:
• reference compound in antileishmanial activity
• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.

Recommended for use in cell culture applications at 100mg/L.

Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

생화학적/생리학적 작용

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

기타 정보

1g,5g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable