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Merck
모든 사진(1)

Key Documents

P3982

Sigma-Aldrich

[Pro34]-Peptide YY

≥95%

로그인조직 및 계약 가격 보기


About This Item

실험식(Hill 표기법):
C194H294N54O56
Molecular Weight:
4278.74
MDL number:
UNSPSC 코드:
12352209
NACRES:
NA.77

Quality Level

분석

≥95%

형태

powder

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

human ... PYY(5697)

Amino Acid Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Pro-Arg-Tyr-NH2

일반 설명

Peptide YY (PYY) is synthesized by L cells in the mucosa of the distal ileum, colon, and rectum. It is mainly expressed by peripheral blood mononuclear cells. Peptide YY is located on human chromosome 17q21.

생화학적/생리학적 작용

Peptide YY (PYY) is involved in the modulation of gut motility, food intake and insulin secretion and is associated with obesity and type 2 diabetes. It may possess systemic and paracrine functions. NPY agonist with a preference for the Y1 and Y5 subtypes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

N D Holliday et al.
Canadian journal of physiology and pharmacology, 78(2), 126-133 (2000-03-29)
This investigation describes the relative potencies of four peptide agonists, namely, peptide YY (PYY), [Leu3l,Pro34]PYY (Pro34pYY), neuropeptide Y (NPY), and [Leu31,Pro34]NPY (Pro34NPY), as antisecretory agents in human, rat, and mouse gastrointestinal preparations. The inhibition of agonist responses by the Y1-receptor
TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways
Larraufie P, et al.
Cellular Microbiology, 19(2), e12648-e12648 (2017)
K Kawakubo et al.
Brain research, 854(1-2), 30-34 (2000-04-28)
We previously reported that intracisternal (i.c.) injection of peptide YY (PYY) and low doses of thyrotropin-releasing hormone (TRH) or TRH analog, RX 77368, increased the resistance of the gastric mucosa to ethanol injury through vagal pathways in rats. The gastroprotective
Julia Pia Natascha Holler et al.
Peptides, 58, 78-82 (2014-06-28)
Peptide YY is produced by L cells in the mucosa of the distal ileum, colon, and rectum and may have systemic and paracrine functions. We hypothesized that peptide YY is expressed by peripheral blood mononuclear cells. The purpose of the
Y Hort et al.
Genomics, 26(1), 77-83 (1995-03-01)
Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are structurally related but functionally diverse peptides, encoded by separate genes and expressed in different tissues. Although the human NPY gene has been mapped to chromosome 7, we demonstrate here

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