P2116

Pirfenidone

≥97% (HPLC), powder, antifibrotic agent

• 동의어(들): 5-Methyl-1-phenyl-2-(1H)-pyridone
• 실험식(Hill 표기법): C₁₂H₁₁NO
• CAS Number: 53179-13-8
• Molecular Weight: 185.22
• MDL number: MFCD00866047
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278625
• NACRES: NA.77

속성

• product name: Pirfenidone, ≥97% (HPLC)
• 분석: ≥97% (HPLC)
• 형태: powder
• solubility: H₂O: >10 mg/mL at 60 °C (warming for 30 minutes); DMSO: >20 mg/mL
• 주관자: Shionogi
• SMILES string: O=C(C=CC(C)=C1)N1C2=CC=CC=C2
• InChI: 1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
• InChI key: ISWRGOKTTBVCFA-UHFFFAOYSA-N

설명

일반 설명

Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.

애플리케이션

Pirfenidone has been used:

• as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery
• as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit
• to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)
• as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia

생화학적/생리학적 작용

Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.

Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon′s fibroblasts.

특징 및 장점

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves