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Merck
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Key Documents

P0359

Sigma-Aldrich

Palmitoylethanolamide

≥98% (HPLC), powder, cannabinoid receptor agonist

동의어(들):

N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol

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About This Item

실험식(Hill 표기법):
C18H37NO2
CAS Number:
Molecular Weight:
299.49
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

product name

Palmitoylethanolamide,

형태

powder

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCCCCC(=O)NCCO

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

InChI key

HXYVTAGFYLMHSO-UHFFFAOYSA-N

유전자 정보

애플리케이션

Palmitoylethanolamide has been used as a reference standard in mass spectrometry (MS/MS).

생화학적/생리학적 작용

Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. It is found in soybeans, egg yolk, and many other food sources. PEA is an endogenous cannabinoid receptor agonist. It is a peroxisome proliferator-activated receptor α (PPAR-α) ligand. PEA possesses anti-inflammatory, anti-allergic, neuroprotective, and analgesic activities. It belongs to the class of lipid mediators and the N-acylethanolamine family. PEA blocks the release of pro-inflammatory mediators from activated mast cells and prevents the recruitment of activated mast cells at the site of nerve injury.

결합

Structural analog of anandamide.

픽토그램

CorrosionEnvironment

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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Melania Melis et al.
The Laryngoscope, 129(9), E307-E312 (2019-01-25)
Taste sensitivity varies greatly among individuals influencing eating behavior and health, consequently the disorders of this sense can affect the quality of life. The ability to perceive the bitter of thiourea compounds, such as phenylthiocarbamide (PTC), has been largely reported
Didier M Lambert et al.
Current medicinal chemistry, 9(6), 663-674 (2002-04-12)
The discovery of anandamide as an endogenous ligand for the cannabinoid receptors has led to a resurgence of interest in the fatty acid amides. However, N-palmitoylethanolamine (PEA), a shorter and fully saturated analogue of anandamide, has been known since the
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Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and β-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1). TAAR1 has been implicated in human conditions including obesity, schizophrenia, depression, fibromyalgia, migraine, and addiction. Additionally TAAR1 is
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American journal of obstetrics and gynecology, 215(5), 609-609 (2016-10-30)
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Journal of chromatographic science, 54(8), 1428-1434 (2016-05-04)
This article aims to build up a simple, rapid and accurate capillary zone electrophoresis (CZE) method for the separation of biogenic amines (BAs). Here, 10 key BAs (phenethylamine, histamine, tryptamine, tyramine, 5-hydroxytryptamine, octopamine, dopamine, norepinephrine, epinephrine and carnosine) owning significant

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