O3514

Osteopontin from bovine milk

lyophilized powder

• 동의어(들): Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)
• MDL number: MFCD03100698
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: bovine milk
• Quality Level: 100
• 무균: sterile
• 형태: lyophilized powder
• 분자량: ~60 kDa
• 포장: pkg of 50 μg
• 기술: cell culture | mammalian: suitable
• UniProt 수납 번호: P31098; P31096
• 배송 상태: ambient
• 저장 온도: −20°C
• 유전자 정보: cow ... SPP1(281499)

설명

일반 설명

Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.

생화학적/생리학적 작용

A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.

Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

분석 메모

The biological activity is measured by its ability to mediate 293 cell adhesion.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)