Neuraminidase from Vibrio cholerae

Name: Neuraminidase from <I>Vibrio cholerae</I>
Brand: SIGMA

Type III, buffered aqueous solution, 0.2 μm filtered, 1-5 units/mg protein (Lowry, using NAN-lactose)

동의어(들):

Acyl-neuraminyl Hydrolase, Receptor-destroying enzyme, Sialidase

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About This Item

CAS Number:

9001-67-6

EC 번호:

3.2.1.18 (BRENDA, IUBMB)

EC Number:

232-624-6

MDL number:

MFCD00131711

UNSPSC 코드:

12352204

NACRES:

NA.54

Quality Level

300

유형

Type III

양식

buffered aqueous solution

특이 활성도

1-5 units/mg protein (Lowry, using NAN-lactose)

분자량

83 kDa

응용 분야

diagnostic assay manufacturing

외래 활성

Protease and NAN-aldolase, present

저장 온도

2-8°C

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일반 설명

Neuraminidase enzymes are glycoside hydrolase enzymes that catalyze hydrolysis of terminal sialic acid residues. The most well-known are the viral nearamidases, which promote influenza virus release.

애플리케이션

Neuraminidase from Vibrio cholerae has been used in a study to assess its role in the binding and uptake of cholera toxin by susceptible cells. It has also been used in a study to investigate the preparation of a sodium substrate and its use in a fluorometric assay of neuraminidase.

Neurminidase is used as a cell-surface probe for glycoconjugate distribution and in substrate specificity studies.

생화학적/생리학적 작용

Vibrio cholerae neuraminidase has been shown to promote cholera toxin infection by binding the toxin and aiding in its uptake by cells.

품질

Preservative free.

단위 정의

One unit will liberate 1.0 μmole of N-acetylneuraminic acid per min at pH 5.0 at 37 °C using NAN-lactose or bovine submaxillary mucin, unless otherwise specified. Prices based on units using NAN-lactose as substrate.