N7537

NSC 663284

≥98% (HPLC), solid

• 동의어(들): 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• 실험식(Hill 표기법): C₁₅H₁₆ClN₃O₃
• CAS Number: 383907-43-5
• Molecular Weight: 321.76
• MDL number: MFCD08276924
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724556
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 저장 조건: protect from light
• 색상: red
• solubility: DMSO: ≥10 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• InChI key: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• 유전자 정보: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

설명

애플리케이션

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

생화학적/생리학적 작용

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): 470.1 °F
• Flash Point (°C): 243.4 °C
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves