N5538

Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse

clone 18G4, purified immunoglobulin, buffered aqueous glycerol solution

• UNSPSC 코드: 12352203
• NACRES: NA.41
• 결합: unconjugated
• application: WB
• 클론: 18G4, monoclonal
• 종 반응성: wide range
• citations: 17
• 기술: western blot: 1:1,000 using mouse and rat brain

속성

• 생물학적 소스: mouse
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 18G4, monoclonal
• 양식: buffered aqueous glycerol solution
• 분자량: antigen ~55 kDa
• 종 반응성: wide range
• 기술: western blot: 1:1,000 using mouse and rat brain
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: nitration (Tyr)
• 유전자 정보: human ... NOS1(4842)

설명

일반 설명

3-nitrotyrosine (3-NT) is synthesized by the incorporation of nitro triatomic group (-NO₂) at the third position of the phenolic ring in the tyrosine residue, in response to the production of peroxynitrite in the oxidative and nitrosative stress.

면역원

3-Nitrotyrosine-KLH.

애플리케이션

Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse has been used in western blot analysis and immunohistochemistry.

생화학적/생리학적 작용

3-Nitrotyrosine (3-NT) in tissue extracts is a marker for the determination of protein damage induced by peroxynitrite. 3-NT is used as a biomarker to determine the protein nitration, associated with various disorders. It is implicated in diseases characterized by endothelial dysfunction as in stroke, myocardial infarction, atherosclerosis and diabetes.

표적 설명

Monoclonal Anti-3-Nitrotyrosine recognizes 3-nitrotyrosine in most species. Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling.

물리적 형태

Solution in 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, and 3 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable